There are already many liberals in the red states doing what they can, down to buying houses based on districting and local politics. If you have the means, why not join them? As President Obama pointed out, there are millions of good people in the red states. If you're nearing retirement, the South is chock full of gorgeous communities with all the amenities you could imagine, and you will never be cold again if you travel somewhere warmer during January. Just imagine: no snow. Ever. You'll forget what a windshield scraper even looks like.
If you telecommute or work from home, why not do it from paradise? The cost of living is relatively low in places like Asheville and the Charleston area, and probably many other places I don't know about, but arts and music abound. If I had all my needs met and worked from home, I'd live in Folly Beach, SC, seen above in its entirety. It's a quirky little beach town with tons of character and a great music scene due to its proximity to Charleston, and the beach is nearly deserted half the year. Many people would hate it, but it would be perfect for me. Find your quirky little town.
If you're thinking of starting a small business, many Southern towns are very welcoming of new industry. Pay a living wage and provide basic benefits and you'll have the most hard-working and devoted workforce you could hope to find, while setting the bar higher for other employers in your area.
Many people can't move for various entirely valid reasons, but I've heard from a lot of people who are contemplating a big move. The population seems to be becoming more mobile. It's getting easier and easier, thanks to the Internet, to simply migrate. If you're contemplating a move, please check out the South. It's a great place to live, filled with excellent people. Most importantly, progressives getting involved in local politics in the South would save people's lives and help heal the nation.